Metabolic signatures of birthweight in 18 288 adolescents and adults

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Metabolic signatures of birthweight in 18 288 adolescents and adults

BACKGROUND Lower birthweight is associated with increased susceptibility to cardiometabolic diseases in adulthood, but the underlying molecular pathways are incompletely understood. We examined associations of birthweight with a comprehensive metabolic profile measured in adolescents and adults. METHODS High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used t...

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Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability to form clear-cut threat categories, allowing pervasive fears to manifest. Here...

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ژورنال

عنوان ژورنال: International Journal of Epidemiology

سال: 2016

ISSN: 0300-5771,1464-3685

DOI: 10.1093/ije/dyw255